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Methylation Support

Methylation Support

Methylation Support Supplements

  • B12 (Methylcobalamin, Hydroxycobalamin, Adenosylcobalamin)
  • Methyl Folate, 5-MTHF (5-Methyltetrahydrofolic)
  • SAMe, S-Adenosyl Methionine


The role of the methylation cycle in your body
The methylation cycle is the ideal pathway to focus on for nutritional genetic analysis because the places where mutations occur is well defined and it is clear where supplements can be added to go around these mutations.
The function of the methylation cycle is essential for a number of critical reactions in the body. One consequence of genetic weaknesses (mutations) in this pathway is increased risk factors for a number of serious health conditions. Defects in methylation lay the appropriate groundwork for the further assault of environmental and infectious agents resulting in a wide range of conditions including diabetes, cardiovascular disease, thyroid dysfunction, neurological inflammation, chronic viral infection, neurotransmitter imbalances, atherosclerosis, cancer, aging, schizophrenia, decreased repair of tissue damage, improper immune function, neural tube defects, Down’s syndrome, Multiple Sclerosis, Huntington’s disease, Parkinson’s disease, Alzheimer’s disease, and autism, Inflammation, bacterial, and viral infection



Methylation uses the process of donating ‘Methyl Groups’ to a substrate

  • A Methyl Group = 1 Carbon bound to 3 Hydrogens = CH3 

  • Methyl groups substrates are commonly, but not limited to: 

    • DNA and RNA, 

    • chemicals, 

    • Neurotransmitters and hormones, 

    • immune cells, 

    • nerves 


Functions of Methylation

  1. Turn on and off genes (gene regulation) 

  2. Process chemicals and toxins (biotransformation) 

  3. Build neurotransmitters (dopamine, serotonin, epinephrine) 

  4. Process hormones (estrogen) 

  5. Build immune cells (T cells, NK cells) 

  6. DNA and RNA synthesis

  7. Produce energy (CoQ10, carnitine, ATP) 

  8. Produce protective myelination coating on nerves

Methylation can be disturbed by: 

  1. Lack of cofactors driving methylation forward (zinc, magnesium, B6) 

  2. Medications (antacids) 

  3. Specific nutrients depleting methyl groups (niacin) 

  4. Environmental toxicity, heavy metals, chemicals (acetylaldehyde, arsenic, mercury) 

  5. Excessive substrate (feedback inhibition) 

  6. Genetic mutations 


Signs of methylation issues

Hair loss, brittle
Brain anxiety, depression, ADHS, Autism, memory loss, Alzheimer's, insomnia, restless legs, shizophrenia, bipolar disorders
Eyes teary, redness
Ears Tinnitus
Thyroid hypothyroid
Heart hypotension, strokes, clots
 Skin easy bruising, rashes, eczema, vitiligo, psoriasis, poor wound healing, pigmentation
 Nails  brittle, ridges
 Hormone  low estrogen, testosterone
 Energy  fatigue
 Allergies  food, celiac
 Fertility  neural tube defects, infertility, miscarriages
 Muscles  fibromyalgia, muscle pains
 Immune  fungus, virus, sinusitis


Genetic SNP Mutations

Many people have mutations in their methylation pathways. Because of this it is necessary to use the 5-MTHF form. If you are not sure, we offer easy to perform genetic tests for methylation.

  • MTHFR C677T        -- 0% loss; +- 40% loss; ++ 70% loss of function
  • MTHFR A1298C      -- 0% loss; +- 20% loss; ++ 40% loss of function



Remember, restarting the mehtylation pathway can start major detoxification of metals, chemicals and viruses. So your mantra should be "Start low, go slow." This means start with low does and slowly increase until you get to the desired dose

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